2-(trifluoromethyl)imidazo[1,2-a]pyrazine → 2-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine

HRID 920969

Reaktionsgleichung

Reaktionsgleichung von HRID 920969
[F:1][C:2]([F:13])([F:12])[C:3]1[N:4]=[C:5]2[CH:10]=[N:9][CH:8]=[CH:7][N:6]2[CH:11]=1>CO.[Pd]>[F:12][C:2]([F:1])([F:13])[C:3]1[N:4]=[C:5]2[CH2:10][NH:9][CH2:8][CH2:7][N:6]2[CH:11]=1

Komponenten

4

Edukt 1

HCID 32313062-(trifluoromethyl)imidazo[1,2-a]pyrazine

Produkt 1

HCID 147199282-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazineAusbeute 95,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

2-(Trifluoromethyl)imidazo[1,2-a]pyrazine 12b (2.40 g, 12.55 mmol) was dissolved in 100 mL of methanol, followed by addition of Pd—C (10%, 480 mg), and the reactor was purged with hydrogen for three times. After stirring for 12 hours, the reaction mixture was filtered and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to obtain 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 12c (2.30 g, yield 95.8%) as a yellow oil.

Aufarbeitung

  1. customthe reactor was purged with hydrogen for three times
  2. filtrationthe reaction mixture was filtered
  3. washthe filter cake was washed with methanol
  4. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-08587bb78867441481980e766d248433
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09273052B2

Verknüpfte Notizen

Wird geladen…