Water → Budenoside
Reaktionsgleichung
O.C[CH2:3][CH2:4][CH:5]1[O:25][C@:24]2([C:26]([CH2:28][OH:29])=[O:27])[C@@H:7]([CH2:8][C@@H:9]3[C@:23]2([CH3:30])[CH2:22][C@H:21]([OH:31])[C@H:20]2[C@H:10]3[CH2:11][CH2:12][C:13]3[C@:19]2([CH3:32])[CH:18]=[CH:17][C:15](=[O:16])[CH:14]=3)[O:6]1>ClCCl>[CH3:3][CH2:4][CH:5]1[O:25][C@:24]2([C:26]([CH2:28][OH:29])=[O:27])[C@@H:7]([CH2:8][C@@H:9]3[C@:23]2([CH3:30])[CH2:22][C@H:21]([OH:31])[C@H:20]2[C@H:10]3[CH2:11][CH2:12][C:13]3[C@:19]2([CH3:32])[CH:18]=[CH:17][C:15](=[O:16])[CH:14]=3)[O:6]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Water (800 mL) was charged to a 1 L stirred crystallizer fitted with a thermo-regulation jacket. The temperature was adjusted to 45° C. Water was pumped around a recirculation loop using a diaphragm pump (operating at 20 L/h) and a 250 ml thermo-regulated glass ultrasonic flow-cell fitted with a 30 mm diameter 20 kHz ultrasonic probe. The probe was held at the highest position in the flow-cell and sealed/clamped at a point of zero vibration (null point). The flow-cell was thermo-regulated at 45° C. Continuous ultrasound was applied at 15 W power, 5 micron amplitude. Budesonide (0.8 g) was dissolved in dichloromethane (80 mL). The solution was dispersed in an aqueous phase held at 45° C. consisting of 800 ml of a 0.2% (w/v) solution of Tween 80. The dichloromethane solution was pumped into the ultrasonic flow-cell using a second inlet on the underside of the flow-cell at a rate of 20 ml/h. The resulting suspension was stirred for 30 minutes at 300 rpm with sonication. Product was collected as aqueous suspension.