C(O[C:5]1[C:10]2C=CO[C:9]=2[CH:8]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=O)[CH:6]=1)(=O)C.[C:19](=[O:22])([O-])[O-].[K+].[K+].[CH3:25][C:26]1[CH:31]=[CH:30][C:29](S(OCCCOC)(=O)=O)=[CH:28][CH:27]=1.[OH2:41].[C:42](#N)[CH3:43]>>[CH2:14]([O:16][C:17]1[CH:18]=[CH:25][C:26]([C:31](=[O:41])[CH3:30])=[CH:27][C:28]=1[CH2:29][CH2:42][CH2:43][O:22][CH3:19])[C:7]1[CH:6]=[CH:5][CH:10]=[CH:9][CH:8]=1To a solution of the compound obtained in the above (1) (11.0 g) in acetonitrile (113 mL) were added potassium carbonate (9.37 g) and 3-methoxypropyl 4-methylbenzene sulfonate (13.2 g), and the mixture was heated to reflux for 20 hours. The reaction solution was cooled to room temperature, and then thereto was added water, and the mixture was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was triturated with diisopropyl ether to give 1-[4-(benzyloxy)-3-(3-methoxypropyl)phenyl]ethanone [REx(26-2)] (8.75 g) as a colorless powder.
Wird geladen…
