1-Ethenyl-4-(trifluoromethyl)benzene → 4-Ethylbenzotrifluoride

HRID 924671

Reaktionsgleichung

Reaktionsgleichung von HRID 924671
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][CH:4]=1)=[CH2:2]>C1COCC1.[Pd]>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]([F:10])([F:11])[F:12])=[CH:7][CH:8]=1)[CH3:2]

Komponenten

4

Edukt 1

HCID 27827981-Ethenyl-4-(trifluoromethyl)benzene

Produkt 1

HCID 53246974-Ethylbenzotrifluoride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 1-ethenyl-4-(trifluoromethyl)benzene (1.72 mL, 11.6 mmol) in THF (60 mL) was stirred in the presence of Pd/C (10%, 400 mg), under a hydrogen atmosphere (45 psi) for 7 h. The solid was filtered through celite (washed with DCM) and the filtrate was carefully concentrated, keeping the temperature of the bath below 20° C. at 200 mmHg. The concentrated solution thus obtained was used in the next step without further manipulation.

Aufarbeitung

  1. filtrationThe solid was filtered through celite (washed with DCM)
  2. concentrationthe filtrate was carefully concentrated
  3. customthe temperature of the bath below 20° C.
  4. customThe concentrated solution thus obtained

Quellen und Nachweise

ORD-Eintrag
ord-be6e3d4980564493a300094b7485178b
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09283224B2

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