Hydrazine hydrate (1:1) → 6-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

HRID 926735

Reaktionsgleichung

Reaktionsgleichung von HRID 926735
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[N:8][CH:9]=1)([O-])=O.O.NN>[Ni].C(O)C.CO>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH:14]=[N:13][CH:12]=[N:11]1

Komponenten

6

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

Produkt 1

HCID 167723276-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

Raney nickel (0.650 g) was added to a solution of 5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine (3.2 g, 16.7 mmol) in a mixture of ethanol and methanol (1:1) (150 mL) followed by the addition of Hydrazine hydrate (2.51 g, 50.2 mmol) and stirring was continued at 25° C. 1 hr. The reaction mixture was filtered over celite bed and washed with methanol. The filtrate and the washings were concentrated under reduced pressure to afford title compound as pale brown liquid. MS (ESI): m/z 162.1 (M+H).

Aufarbeitung

  1. customwas continued at 25° C
  2. custom1 hr
  3. filtrationThe reaction mixture was filtered over celite bed
  4. washwashed with methanol
  5. concentrationThe filtrate and the washings were concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e0ba472449004b1f9bcbfae8f21479ea
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09289419B2

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