Ammonium Hydroxide → 3-(5-Bromo-2-fluorobenzoylamino)pyrazine-2-carboxamide

HRID 928261Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 928261
C[O:2][C:3]([C:5]1[C:10]([NH:11][C:12](=[O:21])[C:13]2[CH:18]=[C:17]([Br:19])[CH:16]=[CH:15][C:14]=2[F:20])=[N:9][CH:8]=[CH:7][N:6]=1)=O.[NH4+:22].[OH-]>C(O)C>[Br:19][C:17]1[CH:16]=[CH:15][C:14]([F:20])=[C:13]([CH:18]=1)[C:12]([NH:11][C:10]1[C:5]([C:3]([NH2:22])=[O:2])=[N:6][CH:7]=[CH:8][N:9]=1)=[O:21]

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 577423823-(5-bromo-2-fluorobenzoylamino)pyrazine-2-carboxylic Acid Methyl Ester

Produkt 1

HCID 577423843-(5-Bromo-2-fluorobenzoylamino)pyrazine-2-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 3-(5-bromo-2-fluorobenzoylamino)pyrazine-2-carboxylic acid methyl ester 102 (2.6 g, 7.34 mmol) and NH4OH (15 mL) in ethanol (50 mL) was heated at reflux for 10 min. Then, the reaction mixture was cooled at room temperature and the precipitate was filtered off, washed with ethanol and ether to give 2.1 g of the title product 103 as a white powder (LCMS analysis).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 10 min
  3. filtrationthe precipitate was filtered off
  4. washwashed with ethanol and ether

Quellen und Nachweise

ORD-Eintrag
ord-69d79c10a6a24885b5886e0cebd64be8
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290502B2

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