Lithium Hydroxide → 2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(trifluoromethylsulfonamido)butan-2-yl)piperidin-3-yl)acetic acid
Reaktionsgleichung
ClC1C=C([C@@H]2[C@@H](C3C=CC(Cl)=CC=3)N([C@@H](CC)CO)C(=O)[C@](CC(OC)=O)(C)C2)C=CC=1.C(P(CCCC)(CCCC)=CC#N)CCC.FC(F)(F)S(N)(=O)=O.[Cl:57][C:58]1[CH:59]=[C:60]([C@@H:64]2[C@@H:69]([C:70]3[CH:75]=[CH:74][C:73]([Cl:76])=[CH:72][CH:71]=3)[N:68]([C@@H:77]([CH2:87][CH3:88])[CH2:78][NH:79][S:80]([C:83]([F:86])([F:85])[F:84])(=[O:82])=[O:81])[C:67](=[O:89])[C@:66]([CH2:91][C:92]([O:94]C)=[O:93])([CH3:90])[CH2:65]2)[CH:61]=[CH:62][CH:63]=1.[Li+].[OH-]>C1(C)C=CC=CC=1.C(O)C>[Cl:57][C:58]1[CH:59]=[C:60]([C@@H:64]2[C@@H:69]([C:70]3[CH:71]=[CH:72][C:73]([Cl:76])=[CH:74][CH:75]=3)[N:68]([C@@H:77]([CH2:87][CH3:88])[CH2:78][NH:79][S:80]([C:83]([F:86])([F:85])[F:84])(=[O:82])=[O:81])[C:67](=[O:89])[C@:66]([CH2:91][C:92]([OH:94])=[O:93])([CH3:90])[CH2:65]2)[CH:61]=[CH:62][CH:63]=1Komponenten
8
Edukt 5
HCID 3939Lithium Hydroxide
HCID 79001Trifluoromethylsulfonamide
HCID 4622928Cyanomethylenetributylphosphorane
HCID 58573771Methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-hydroxybutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetate
HCID 67998602methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(trifluoromethylsulfonamido)butan-2-yl)piperidin-3-yl)acetate
