Bicarbonate Ion → 4-{4-[4-Fluoro-3-(1-methylpiperidin-4-yl)-phenyl-amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

HRID 946796Notizen

Reaktionsgleichung

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][c:16]3[c:17]([n:18][cH:19][n:20][c:21]3[Cl:22])[nH:23]2)=[CH:12][CH2:13]1.[C:46](=[O:47])([OH:48])[O-:49].[C:51]([O:52][C:53]([O:54][C:55]([O:56][C:57]([CH3:58])([CH3:59])[CH3:60])=[O:61])=[O:62])([CH3:63])([CH3:64])[CH3:65].[CH3:66][CH2:67][O:68][C:69]([CH3:70])=[O:71].[CH3:72][N:73]([CH3:74])[CH:75]=[O:76].[F:24][c:25]1[c:26]([CH:32]2[CH2:33][CH2:34][N:35]([CH3:38])[CH2:36][CH2:37]2)[cH:27][c:28]([NH2:31])[cH:29][cH:30]1.[Na+:50].[OH:39][C:40]([C:41]([F:42])([F:43])[F:44])=[O:45]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][c:16]3[c:17]([n:18][cH:19][n:20][c:21]3[NH:31][c:28]3[cH:27][c:26]([CH:32]4[CH2:33][CH2:34][N:35]([CH3:38])[CH2:36][CH2:37]4)[c:25]([F:24])[cH:30][cH:29]3)[nH:23]2)=[CH:12][CH2:13]1