Ethyl bromoacetate → Ethyl 2-(2-(trifluoromethyl)phenoxy)acetate

HRID 9623

Reaktionsgleichung

Reaktionsgleichung von HRID 9623
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>C(#N)C.O.C(OCC)(=O)C>[CH2:23]([O:22][C:20](=[O:21])[CH2:19][O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:10])([F:11])[F:1])[CH3:24]

Komponenten

7

Edukt 3

HCID 7748Ethyl bromoacetateHCID 10796Cesium carbonateHCID 679582-Trifluoromethylphenol

Produkt 1

HCID 11354946Ethyl 2-(2-(trifluoromethyl)phenoxy)acetate

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 6342AcetonitrileLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 2-trifluoromethylphenol (1.62 g) in anhydrous acetonitrile was treated with cesium carbonate (3.25 g) and ethyl bromoacetate (1.75 g) and the reaction mixture stirred at room temperature for 2 hours. The reaction mixture was diluted with water and ethyl acetate and the organic layer washed with water and dried with brine and over sodium sulfate. Evaporation of ethyl acetate gave the title compound as a colourless oil.

Aufarbeitung

  1. washthe organic layer washed with water
  2. dry with materialdried with brine and over sodium sulfate
  3. customEvaporation of ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-6d696bea668f4b758ccefed342a68beb
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091237B2

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