Reaktionsgleichung
C/C=C/c1ccccc1.CC(C)(C)C(=O)ON(Cc1ccccc1)Cc1ccccc1>C1CCOC1.CC(=O)[O-].CC(=O)[O-].CO[Si](C)OC.COc1c(C(C)(C)C)cc(P(c2cc(C(C)(C)C)c(OC)c(C(C)(C)C)c2)c2ccc3c(c2-c2c(P(c4cc(C(C)(C)C)c(OC)c(C(C)(C)C)c4)c4cc(C(C)(C)C)c(OC)c(C(C)(C)C)c4)ccc4c2OCO4)OCO3)cc1C(C)(C)C.[Cu+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>CC[C@H](c1ccccc1)N(Cc1ccccc1)Cc1ccccc1Komponenten
8
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 5
Reaktionsbedingungen
- Temperatur
- 23 °C
- Sonstiges
- After dropwise addition of dimethoxy(methyl)- silane into reaction mixture in water bath, the vessel was removed and allowed to stir for an additional 12 hours
Aufarbeitung
- additionKeine Vorschrift aufgezeichnet
- additionKeine Vorschrift aufgezeichnet
- additionKeine Vorschrift aufgezeichnet
- additionKeine Vorschrift aufgezeichnet
- extraction3 x 50 mL ethyl acetate extraction · organic-Phase beibehalten
- concentrationrotary evaporator (35 degC, 50 mmHg)
- flash chromatographyThe crude reaction mixture is dissolved in a minimal quantity of benzene or toluene and is loaded onto a column, with interior diameter of roughly 2 inches, packed with silica (200 g, SiliCycle, F60/230-400 mesh) and equilibrated with hexanes. The column is eluted under air pressure with hexanes (500 mL), then 1% ethyl acetate in hexanes (1 L), then 2% ethyl acetate in hexanes (1 L). During elution, fractions are collected in test tubes (roughly 28 mL each), and the desired product typically elutes around fractions 18 through 66. The fractions that contain the productare combined
- concentrationrotary evaporator (30 degC, 80 mmHg)
Quellen und Nachweise
- ORD-Eintrag
- ord-7b927700e3414788865b46a4d4b18c44
- Quelldatensatz
- Copper-Catalyzed Enantioselective Hydroamination of Alkenes
- Originallink
- Quelle ansehen
Verknüpfte Notizen
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