4-Chlorophenol → 1-Chloro-4-(2-chloroethoxy)benzene

HRID 962460

Reaktionsgleichung

Reaktionsgleichung von HRID 962460
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Br[CH2:10][CH2:11][Cl:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH2:11][Cl:12])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 46844-ChlorophenolHCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium Carbonate

Produkt 1

HCID 830341-Chloro-4-(2-chloroethoxy)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 4-chlorophenol (100 g), 1-bromo-2-chloroethane (335 g), potassium carbonate (129 g) and acetone (2 l) was boiled under reflux with stirring for 18 hours. The mixture was evaporated to dryness under reduced pressure and then dichloromethane was added to the cool residue. The mixture was filtered and the filtrate washed with 5M sodium hydroxide solution, water, dried, filtered and evaporated to give 2-chloroethyl 4-chlorophenyl ether as an oil.

Aufarbeitung

  1. temperatureunder reflux
  2. customThe mixture was evaporated to dryness under reduced pressure
  3. additiondichloromethane was added to the cool residue
  4. filtrationThe mixture was filtered
  5. washthe filtrate washed with 5M sodium hydroxide solution, water
  6. customdried
  7. filtrationfiltered
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-aa8d150336f2442bbe8ed61e251865ce
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05760035

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