4-Carbamoyl-1-phenylpyridinium chloride → 1-Phenylpiperidine-4-carboxamide

HRID 963998Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 963998
[Cl-].[C:2]([C:5]1[CH:10]=[CH:9][N+:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])[NH2:3]>[Pd].C(O)C>[C:11]1([N:8]2[CH2:9][CH2:10][CH:5]([C:2]([NH2:3])=[O:4])[CH2:6][CH2:7]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

4

Edukt 1

HCID 107048844-Carbamoyl-1-phenylpyridinium chloride

Produkt 1

HCID 105843391-Phenylpiperidine-4-carboxamideAusbeute 52,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 4-carbamoyl-1-phenylpyridinium chloride (13 g), 10% palladium-on-carbon catalyst (260 mg) and ethanol (250 ml) was hydrogenated at ambient temperature and pressure for 2 days. The solution was filtered (Celite) and the filtrate was concentrated to approximately 50 ml. This solution was cooled and the solid precipitate collected by filtration to give 1-phenylpiperidine-4-carboxamide (5.99 g).

Aufarbeitung

  1. customwas hydrogenated at ambient temperature
  2. filtrationThe solution was filtered (Celite)
  3. concentrationthe filtrate was concentrated to approximately 50 ml
  4. temperatureThis solution was cooled
  5. filtrationthe solid precipitate collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-a11b4d6683ae48778c67323737e82d03
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05767116

Notizen zur Reaktion

Wird geladen…