Water → 4-Azidobutanoic Acid

Temperatur

0 °C

Ethyl 4-azidobutyrate (8.06 g, 51.3 mmol) and KOH (14.4 g, 0.256 mol) were dissolved into a mixture of 100 ml of water and 120 ml of MeOH. The solution was stirred at 0° C. for 2 hrs and then MeOH was removed in vacuo. The aqueous layer was extracted by CHCl3 (50 ml), acidified to pH=1 by 2N aqueous HCl and extracted by Et2O (2×100 ml). The organic layers were combined, washed with water (100 ml) and dried over Na2SO4. After filtration and evaporation of solvent, 4-azidobutyric acid (5.30 g, 80%) was obtained as a colorless oil.

1. customMeOH was removed in vacuo
2. extractionThe aqueous layer was extracted by CHCl3 (50 ml)
3. extractionextracted by Et2O (2×100 ml)
4. washwashed with water (100 ml)
5. dry with materialdried over Na2SO4
6. filtrationAfter filtration and evaporation of solvent

ORD-Eintrag

ord-6e773e57ee114b6bb2f852ce9a11ba7d

Quelldatensatz

uspto-grants-1998_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05767131