Hydrogen Bromide → (R)-2-Bromo-1-[4-phenylmethoxy-3-[(methylsulfonyl)amino]phenyl]ethanol

A 25 mL round bottom flask with magnetic stirbar and toluene-filled Dean-Stark trap with reflux condenser and gas bubbler, was charged with (R)-α,α-diphenyl-2-pyrrolidinemethanol (1.13 g, 4.46 mmol) and trimethylboroxine (418 μL, 2.99 mmol) in toluene (11 mL) under N2. The mixture was stirred at ambient temperature for ~30 minutes and then heated to reflux for 2.75 hours. Upon cooling, this solution was added to a stirred ~-13° C. THF (185 mL) solution under N2 containing 2-bromo-1-[4-phenylmethoxy-3-[(methylsulfonyl)amino]phenyl]ethanone (14.25 g, 36 mmol). To this was added 5.2 mL of 10.1M BH3.Me2S (52 mmol) over ~5 minutes, keeping T≤-11.6° C. Upon completion of the reaction, HBr was bubbled through the solution until the pH was ~1 whereupon a solution of 50 mL MeOH in 100 mL methyl tert-butyl ether was carefully added. The mixture was washed with H2 O (4×100 mL=400 mL) (until the final wash had pH~4-5), diluted with EtOAc (50 mL), dried over Na2SO4. After solvent removal in vacuo, 12.84 g (90%) of crude title compound was obtained in 86% purity with an ee of 96.9%.

1. temperaturewith reflux condenser
2. temperatureheated
3. temperatureto reflux for 2.75 hours
4. temperatureUpon cooling
5. additionthis solution was added to a stirred ~-13° C
6. customT≤-11.6° C
7. customwas bubbled through the solution until the pH was ~1 whereupon a solution of 50 mL MeOH in 100 mL methyl tert-butyl ether
8. additionwas carefully added
9. washThe mixture was washed with H2 O (4×100 mL=400 mL) (until the
10. washfinal wash
11. additiondiluted with EtOAc (50 mL)
12. dry with materialdried over Na2SO4
13. customAfter solvent removal in vacuo

ORD-Eintrag

ord-6e1dc4fb88594d98a582030c30e9bc10

Quelldatensatz

uspto-grants-1998_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05770615