Ammonium formate → HCID 10464367, Verbindung

HRID 965469Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 965469
C([N:8]1[CH2:12][CH2:11][C@@H:10]([C@@H:13]([NH:15][CH3:16])[CH3:14])[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[OH-].[OH-].[Pd+2].C(Cl)Cl.CO>[CH3:16][NH:15][C@H:13]([C@@H:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[CH3:14]

Komponenten

6

Edukt 2

HCID 2723923Ammonium formateHCID 9904942HCID 9904942, Verbindung

Produkt 1

HCID 10464367HCID 10464367, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittelHCID 21226129Dichloromethane methanolLösungsmittel

Versuchsvorschrift

(R,S)-1-benzyl-3-[1'-(methylamino)ethyl]pyrrolidine (0.51 g of crude product) is dissolved in MeOH (10 ml) under a N2 atmosphere, Pearlman's catalyst and ammonium formate (0.89 g, 14.11 mmol) are then added. The reaction mixture is refluxed for 12 hours. The reaction mixture is then diluted with CH2Cl2 :MeOH (1:1) and filtered through a celite pad. The filtrate is washed with 15% aqueous NaOH:brine (1:1) and the aqueous layer is back extracted with CH2Cl2 (2×). The combined organic layers are dried over MgSO4, filtered and concentrated under a stream of N2 to give crude (R,S)-3-[1'-(methylamino)ethyl]pyrrolidine: 1H NMR (300 MHz, CDCl3) δ 1.05 (d, J is 6.3 Hz, 3H), 1.43 (ddd, J is 17, 12, 9 Hz, 1H), 1.87 (m, 1H), 2.02 (dd, J is 16, 8 Hz, 1H), 2.38 (s, 3H), 2.41 (m, 1H), 2.61 (broad s, 2H), 2.65 (dd, J is 11, 8 Hz, 1H), 2.91-3.00 (m, 2H), 3.13 (dd, J is 11, 8 Hz, 1H). This material is suitable for use in various reactions including but not limited to the synthesis of quinolones.

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed for 12 hours
  2. filtrationfiltered through a celite pad
  3. washThe filtrate is washed with 15% aqueous NaOH:brine (1:1)
  4. extractionthe aqueous layer is back extracted with CH2Cl2 (2×)
  5. dry with materialThe combined organic layers are dried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated under a stream of N2

Quellen und Nachweise

ORD-Eintrag
ord-73452398068d447c831ac7386abb3947
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05773610

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