Hydrochloric Acid → HCID 22312200, Verbindung

HRID 965724Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 965724
[CH2:1]([CH:8]1[C:14](=[O:15])[C:13](=[N:16]O)[CH:12]2[CH2:18][CH:9]1[CH2:10][CH2:11]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.Cl.[H][H]>[Pd].C(O)C>[CH2:1]([CH:8]1[C:14](=[O:15])[CH:13]([NH2:16])[CH:12]2[CH2:18][CH:9]1[CH2:10][CH2:11]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 865849682-Aza-2-benzyl-4-oximino-3-oxo-bicyclo[3,2,1]octaneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 22312200HCID 22312200, VerbindungAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-aza-2-benzyl-4-oximino-3-oxobicyclo[3.2.1]octane in 10 mL/mmole of ethanol and 5.8 mL/ mmole of 3N HCl containing 0.5 g/mmole of 10% Pd/C was saturated with hydrogen gas to 45 psi. The mixture was shaken for 3 hours and then filtered through a layer of Celite. The filtrate was dried over sodium sulfate and concentrated under reduced pressure to afford the title compound as a solid (86% yield). This procedure is further described in E. Reimann, Arch. Pharm. 310, 102-109 (1977).

Aufarbeitung

  1. filtrationfiltered through a layer of Celite
  2. dry with materialThe filtrate was dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-eb43efed93c249258ce6084d314b128a
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06951854B1

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