Ethyl cyanoacetate → 6,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic acid ethyl ester

HRID 965783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 965783
[OH:1][C:2]1[CH:9]=[C:8]([OH:10])[C:7]([OH:11])=[CH:6][C:3]=1[CH:4]=O.[C:12]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])#[N:13]>CN(C=O)C.N1CCCCC1.C(O)(=O)C>[CH2:18]([O:17][C:15]([C:14]1[C:12](=[NH:13])[O:1][C:2]2[C:3]([CH:4]=1)=[CH:6][C:7]([OH:11])=[C:8]([OH:10])[CH:9]=2)=[O:16])[CH3:19]

Komponenten

6

Edukt 2

HCID 7764Ethyl cyanoacetateHCID 6433872,4,5-Trihydroxybenzaldehyde

Produkt 1

HCID 1363776256,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidKatalysatorHCID 8082PiperidineKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 2,4,5-trihydroxybenzaldehyde (2.94 g) and ethyl cyanoacetate (1.62 g) in DMF (20 ml) were added 20 drops (Pasteur pipette) of piperidine and eight drops of acetic acid and the solution kept at 80° C. under nitrogen for two hours. The product was filtered and washed with DMF and ethyl ether. Yield: 2.00 g.

Aufarbeitung

  1. filtrationThe product was filtered
  2. washwashed with DMF and ethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-3c8480c2150a4cc39986f0d6baa4f641
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06951870B2

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