Hydrochloric Acid → HCID 21986508, Verbindung

HRID 9660Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 9660
[Br:1][C:2]1[S:6][C:5]([C:7](=[O:9])C)=[C:4]([CH3:10])[CH:3]=1.[BH4-].[Na+].Cl>C(O)C>[Br:1][C:2]1[S:6][C:5]([CH2:7][OH:9])=[C:4]([CH3:10])[CH:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 21986456HCID 21986456, Verbindung2×

Produkt 1

HCID 21986508HCID 21986508, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 1-(5-bromo-3-methylthien-2-yl)ethanone (intermediate 82, 5.13 g) in ethanol (50 ml) was treated with sodium borohydride (0.947 g). The reaction was stirred at 0° C. for 60 minutes and warmed to room temp for 30 minutes. 2M Aqueous hydrochloric acid was added and the reaction mixture was extracted with ethyl acetate twice. The organic solutions were combined and dried with brine and over magnesium sulfate. The title compound was isolated after removal of the desiccant and evaporation of the solvent.

Aufarbeitung

  1. temperaturewarmed to room temp for 30 minutes
  2. extractionthe reaction mixture was extracted with ethyl acetate twice
  3. dry with materialdried with brine and over magnesium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-52cc4b26200a4c778030d3f61d23cf78
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091237B2

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