Sodium 4-methylbenzenesulfonate → 4-Methylphenylbenzylpiperidinium tosylate

HRID 968172

Reaktionsgleichung

Reaktionsgleichung von HRID 968172
[Br-].[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]2([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[C:22]1([CH3:32])[CH:27]=[CH:26][C:25]([S:28]([O-:31])(=[O:30])=[O:29])=[CH:24][CH:23]=1.[Na+]>O>[S:28]([C:25]1[CH:26]=[CH:27][C:22]([CH3:32])=[CH:23][CH:24]=1)([O-:31])(=[O:30])=[O:29].[CH3:2][C:3]1[CH:4]=[CH:5][C:6]([N+:9]2([CH2:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]2)=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 3720192Sodium 4-methylbenzenesulfonateHCID 865888244-Methylphenylbenzylpiperidinium bromide

Produkt 1

HCID 865888254-Methylphenylbenzylpiperidinium tosylateAusbeute 91.980,203 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

An aqueous solution prepared by dissolving 4-methylphenylbenzylpiperidinium bromide (13.85 g, 0.04 mmol) and sodium p-toluenesulfonate (9.32 g, 0.048 mmol) in 50 ml of deionized water was extracted with 50 ml of chloroform twice by using a separating funnel. The resulting chloroform phases were combined and the combined solution was washed with 50 ml of deionized water, followed by filtration and drying to obtain 4-methylphenylbenzylpiperidinium tosylate (16.1 g, yield: 92%).

Aufarbeitung

  1. customAn aqueous solution prepared
  2. extractionwas extracted with 50 ml of chloroform twice
  3. washthe combined solution was washed with 50 ml of deionized water
  4. filtrationfollowed by filtration
  5. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-b93f0cc87f6a45a998414276fb93508a
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06958205B2

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