Oxalyl chloride → 1-(Cyclohexylmethyl)-7-methoxyindole-3-carbonyl chloride

HRID 968637Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 968637
[CH:1]1([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[O:17][CH3:18])[C:10]([C:19]([OH:21])=O)=[CH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:25])=O>C1COCC1>[CH:1]1([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[O:17][CH3:18])[C:10]([C:19]([Cl:25])=[O:21])=[CH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 686950531-(Cyclohexylmethyl)-7-methoxyindole-3-carboxylic acid

Produkt 1

HCID 859058491-(Cyclohexylmethyl)-7-methoxyindole-3-carbonyl chlorideAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 1-(cyclohexylmethyl)-7-methoxyindole-3-carboxylic acid (2.5 g, 8.8 mmol) in THF (30 ml) was added oxalyl chloride (4.5 g, 35.3 mmol), dropwise with stirring. The mixture was stirred at room temperature for 18 h. The volatile components were evaporated under reduced pressure to afford 1-(cyclohexylmethyl)-7-methoxyindole-3-carbonyl chloride (2.7 g) as a crystalline solid.

Aufarbeitung

  1. stirringThe mixture was stirred at room temperature for 18 h
  2. customThe volatile components were evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-af31ea58d986444ca2e570dd23ae8857
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07304064B2

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