Acetic Acid → 3-(2-Anilinopyrimidin-4-yl)benzoic acid
Reaktionsgleichung
[C:1]1([NH:7][C:8]2[N:13]=[C:12]([C:14]3[CH:15]=C([CH:19]=[CH:20][CH:21]=3)C#N)[CH:11]=[CH:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[C:23]([OH:26])(=[O:25])[CH3:24]>>[C:1]1([NH:7][C:8]2[N:13]=[C:12]([C:14]3[CH:15]=[C:24]([CH:19]=[CH:20][CH:21]=3)[C:23]([OH:26])=[O:25])[CH:11]=[CH:10][N:9]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1Komponenten
4
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
To a suspension of 3-(2-phenylamino-pyrimidin-4-yl)-benzonitrile (10 g, 36.7 mmol) in acetic acid (20 mL) was added concentrated hydrochloric acid (30 mL) and the suspension was heated at 100° C. overnight. The starting material completely dissolved and then a solid precipitated. The reaction mixture was filtered and precipitate was washed with ether and methanol to afford 9 g (84%) of the title compound.