HCID 69459677, Verbindung → HCID 69459918, Verbindung

HRID 969465Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 969465
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:20]([OH:35])[CH2:21][NH:22][C:23]([CH3:34])([CH3:33])[CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=2[F:32])=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2)C1C=CC=CC=1>CO.[Pd]>[F:32][C:26]1[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:25]=1[CH2:24][C:23]([NH:22][CH2:21][CH:20]([C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[C:18]2[C:13]=1[CH2:14][CH2:15][C:16](=[O:19])[NH:17]2)[OH:35])([CH3:33])[CH3:34]

Komponenten

4

Edukt 1

HCID 69459677HCID 69459677, Verbindung

Produkt 1

HCID 69459918HCID 69459918, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 220 mg (0.5 mmol) 8-benzyloxy-5-{2-[2-(2,4-difluoro-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-1H-quinolin-2-one in 10 mL methanol is hydrogenated in the presence of palladium on charcoal at ambient temperature and normal pressure. Then the catalyst is separated off, the filtrate is evaporated down and the residue is chromatographed (reverse phase; water/acetonitrile gradient).

Aufarbeitung

  1. customThen the catalyst is separated off
  2. customthe filtrate is evaporated down
  3. customthe residue is chromatographed (reverse phase; water/acetonitrile gradient)

Quellen und Nachweise

ORD-Eintrag
ord-eefb1c3489244838afd841f0be854723
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07307076B2

Notizen zur Reaktion

Wird geladen…