Hydrazine hydrate (1:1) → HCID 25219120, Verbindung

HRID 970269Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 970269
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11](OC)=[O:12])=[O:6].O.[NH2:22][NH2:23]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11]([NH:22][NH2:23])=[O:12])=[O:6]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 723590Methyl 3-(3-chlorobenzamido)benzoate

Produkt 1

HCID 25219120HCID 25219120, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

To a solution of 1.0 gm (3.45 mmol) of methyl 3-(3-chlorobenzamido)benzoate in 24 mL of tetrahydrofuran was added 1.18 mL (34.5 mmol) of hydrazine hydrate. The reaction was heated overnight at 65° C. After cooling, the reaction mixture was concentrated under rotevaporation, and ether and water were added. The solid product was separated by filtration and dried in vacuo to give 3-(3-chlorobenzamido)benzhydrazide. MS m/z: 290.0 (M+H).

Aufarbeitung

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture was concentrated under rotevaporation, and ether and water
  3. additionwere added
  4. customThe solid product was separated by filtration
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6529c36448a44ac8944a27281a11de38
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312181B2

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