Hydrazine hydrate (1:1) → 3-(3-Trifluoromethylbenzamido)benzhydrazide

HRID 970272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 970272
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[C:6]([NH:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12](OC)=[O:13])=[O:7].O.[NH2:25][NH2:26]>O1CCCC1>[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[C:6]([NH:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([NH:25][NH2:26])=[O:13])=[O:7]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 850566Methyl 3-(3-trifluoromethylbenzamido)benzoate

Produkt 1

HCID 694126823-(3-Trifluoromethylbenzamido)benzhydrazideAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 1.0 gm (3.09 mmol) of methyl 3-(3-trifluoromethylbenzamido)benzoate in 19 mL of tetrahydrofuran was added 1.06 mL (30.9 mmol) of hydrazine hydrate. The reaction was heated to reflux for 48 hr. After cooling, the reaction mixture was concentrated under rotevaporation, and ether and water were added. The solid product was separated by filtration and dried in vacuo to give 785 mg (2.43 mmol, 79% yield) of 3-(3-trifluoromethylbenzamido)benzhydrazide as a white solid. MS m/z: 324.0 (M+H).

Aufarbeitung

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 48 hr
  3. temperatureAfter cooling
  4. concentrationthe reaction mixture was concentrated under rotevaporation, and ether and water
  5. additionwere added
  6. customThe solid product was separated by filtration
  7. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-39dd6924c0bb48c6aa397625a13fbac9
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312181B2

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