HCID 23509661, Verbindung → 4-(4-Fluorobenzyl)-1-(3-pyrrolidinylmethyl)piperidine

HRID 970404Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 970404
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH:16]3[CH2:20][CH2:19][N:18](C(OCC4C=CC=CC=4)=O)[CH2:17]3)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[H][H]>[Pd].CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH:16]3[CH2:20][CH2:19][NH:18][CH2:17]3)[CH2:11][CH2:10]2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 23509661HCID 23509661, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 541749794-(4-Fluorobenzyl)-1-(3-pyrrolidinylmethyl)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a stirring solution of 3-[4-(4-flourophenylmethyl)piperidinomethyl]-N-(benzyloxycarbonyl)-pyrrolidine (600 mg, 1.47 mmol) and 5% palladium on carbon (60 mg, Aldrich) in MeOH (50 mL) was added 50 psi of hydrogen. The reaction was stirred for 14 h. The reaction was filtered and the filtrate was conc. in vacuo to a colorless oil. The oil can be used without further purification. MS (ESI) 277 (M+H).

Aufarbeitung

  1. filtrationThe reaction was filtered
  2. customThe oil can be used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-f8229e0edba541a8a7dd0fb2db3cc1e7
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312222B2

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