Sulfadiazine → N-Pyrimidin-2-yl-4-thioformylamino-benzenesulfonamide chloride

HRID 970456

Reaktionsgleichung

Reaktionsgleichung von HRID 970456
[CH:1]1[CH:2]=[N:3][C:4]([NH:7][S:8]([C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[N:5][CH:6]=1.[C:18](Cl)([Cl:20])=[S:19].C(N(CC)CC)C>ClCCl>[Cl-:20].[N:3]1[CH:2]=[CH:1][CH:6]=[N:5][C:4]=1[NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][CH:18]=[S:19])=[CH:13][CH:12]=1)(=[O:10])=[O:9]

Komponenten

5

Edukt 3

HCID 5215SulfadiazineHCID 8471TriethylamineHCID 10040Thiophosgene

Produkt 1

HCID 86601004N-Pyrimidin-2-yl-4-thioformylamino-benzenesulfonamide chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of sulfadiazine (192 mg, 0.77 mmol) in dichloromethane (20 mL) were slowly added thiophosgene (0.06 mL, 0.83 mmol) and triethylamine (0.05 mL, 0.32 mmol) under cooling with an ice bath. After the reaction mixture was stirred for five hours at room temperature, it was washed with water and brine, dried over anhydrous sodium sulfate, filtered, evaporated and dried under vacuum. The product was used immediately for the next reaction.

Aufarbeitung

  1. temperatureunder cooling with an ice bath
  2. washit was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customdried under vacuum
  7. customThe product was used immediately for the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-b37488ecc727401f901f94bb23d8c7ce
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312226B2

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