Morpholine → HCID 14547438, Verbindung

HRID 971203Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 971203
[H-].[Na+].[NH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.Cl.Cl[CH2:11][C:12]([NH2:14])=[NH:13]>C1COCC1>[O:6]1[CH2:7][CH2:8][N:3]([CH2:11][C:12]([NH2:14])=[NH:13])[CH2:4][CH2:5]1

Komponenten

5

Edukt 3

HCID 8083MorpholineHCID 24758Sodium hydrideHCID 27769572-Chloroacetamidine monohydrochloride

Produkt 1

HCID 14547438HCID 14547438, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Sodium hydride (2.4 g, 60 mmol, 60%) was added to a solution of morpholine (5.2 g, 60 mmol) in THF (40 mL, anhydrous) and stirred for 30 min at room temperature under nitrogen. Chloroacetamidine hydrochloride (2.58 g, 20 mmol) was added to this solution in one portion and stirred at 50° C. overnight. Solvent was removed under reduced pressure and the dark brown oily residue was directly used in the next step.

Aufarbeitung

  1. stirringstirred at 50° C. overnight
  2. customSolvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7cf2c5a69a3d4e238f1b207eb22ecc43
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312330B2

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