Sodium Iodide → HCID 12004098, Verbindung

HRID 971252Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 971252
Cl[C:2]1[C:3]2[CH2:11][CH2:10][N:9]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][N:13]=3)[CH2:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:19][N:20]1[CH2:25][CH2:24][O:23][C:22]2[CH:26]=[C:27]([NH2:30])[CH:28]=[CH:29][C:21]1=2.[I-].[Na+]>CC#N>[Cl:18][C:17]1[C:12]([N:9]2[CH2:10][CH2:11][C:3]3[C:2]([NH:30][C:27]4[CH:28]=[CH:29][C:21]5[N:20]([CH3:19])[CH2:25][CH2:24][O:23][C:22]=5[CH:26]=4)=[N:7][CH:6]=[N:5][C:4]=3[CH2:8]2)=[N:13][CH:14]=[CH:15][CH:16]=1

Komponenten

5

Edukt 3

HCID 5238Sodium IodideHCID 112174297-amino-4-methyl-2H-1,4-benzoxazineHCID 590214784-Chloro-7-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Produkt 1

HCID 12004098HCID 12004098, VerbindungAusbeute 16,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
180 °C

Versuchsvorschrift

4-Chloro-7-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (112 mg, 0.36 mmol) and 3,4-dihydro-4-methyl-2H-benzo[b][1,4]oxazin-7-amine (130 mg, 0.72 mmol) were dissolved in CH3CN (3 mL), Sodium iodide (10 mg, 0.06 mmol) was added and the reaction was heated via microwave at 180° C. for 40 minutes. Solvent was removed and the residue was purified by preparative TLC to obtain the product as a beige foam (24 mg).

Aufarbeitung

  1. customSolvent was removed
  2. customthe residue was purified by preparative TLC

Quellen und Nachweise

ORD-Eintrag
ord-d352224a9a3d4dc9961758362e045cea
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312330B2

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