Water → 2,3-Dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate

HRID 971947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 971947
[CH3:1][S:2]([O:5][C:6]1[CH:7]=[CH:8][C:9]2[O:15]S(=O)O[CH2:12][C:11]([CH3:18])([CH3:17])[C:10]=2[CH:19]=1)(=[O:4])=[O:3].[Cl-].[Na+].O>CN(C)C=O>[CH3:1][S:2]([O:5][C:6]1[CH:7]=[CH:8][C:9]2[O:15][CH2:12][C:11]([CH3:18])([CH3:17])[C:10]=2[CH:19]=1)(=[O:4])=[O:3]

Komponenten

5

Edukt 3

HCID 962WaterHCID 5234Sodium ChlorideHCID 233412714,5-Dihydro-5,5-dimethyl-2-oxido-1,3,2-benzodioxathiepin-7-yl methanesulphonate

Produkt 1

HCID 233412912,3-Dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonateAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 4,5-dihydro-5,5-dimethyl-2-oxido-1,3,2-benzodioxathiepin-7-yl methanesulphonate (24 parts) (from Example 20) and sodium chloride (1 part) in dimethyl formamide (400 parts) was boiled under reflux for 3 hours. The mixture was then added to water and the product extracted with ether to give 2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate (16 parts, 84% yield), identical with the product of Example 37(a) above.

Aufarbeitung

  1. temperatureunder reflux for 3 hours
  2. extractionthe product extracted with ether

Quellen und Nachweise

ORD-Eintrag
ord-569aa79264b3425bae0debab94b4f848
Quelldatensatz
uspto-grants-1979_07
Patentnummer
US04162154

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