Isopropylamine → HCID 12801064, Verbindung

HRID 972003Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 972003
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]2[CH2:13][N:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:11][C:10](=[O:20])[O:9]2)=[CH:4][CH:3]=1.[CH:23]([NH2:26])([CH3:25])[CH3:24]>O1CCOCC1>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]([OH:9])[CH2:13][N:12]([CH2:11][C:10]([NH:26][CH:23]([CH3:25])[CH3:24])=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 203059606-[(4-Chlorophenoxy)methyl]-4-phenylmorpholin-2-one

Produkt 1

HCID 12801064HCID 12801064, VerbindungAusbeute 10,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

After 7.0 g (0.22 moles) of 6-(p-chlorophenoxymethyl)-4-phenyl-2-morpholinone and 20 g of isopropylamine were dissolved in 50 ml of dioxane and the resulting Solution was left to stand overnight at room temperature, the reaction mixture was concentrated in vacuo. The residue was solidified by addition of a small amount of ether. The solid was filtered, washed with ether and dried to give 8.7 g of the product. Recrystallization from ethanol afforded 5.5 g (66.3%) of crystals, with a melting point of 140.5° to 142.5°.

Aufarbeitung

  1. waitthe resulting Solution was left
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. additionThe residue was solidified by addition of a small amount of ether
  4. filtrationThe solid was filtered
  5. washwashed with ether
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a51548dc85ff449aa968922aa3098828
Quelldatensatz
uspto-grants-1979_07
Patentnummer
US04162331

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