Hexane → HCID 20309506, Verbindung

HRID 972787Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 972787
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[CH:4]=1.C([Li])CCC.CCCCCC.[CH3:22][N:23]1[C:27](=[O:28])[CH2:26][CH2:25][C:24]1=[O:29]>O1CCCC1>[CH3:22][NH:23][C:24](=[O:29])[CH2:25][CH2:26][C:27](=[O:28])[C:4]1[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[CH:6][C:5]=1[O:9][CH3:10]

Komponenten

6

Edukt 4

HCID 8058HexaneHCID 90251,3-DimethoxybenzeneHCID 70717N-MethylsuccinimideHCID 178418339Butyllithium

Produkt 1

HCID 20309506HCID 20309506, VerbindungAusbeute 93,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of 1,3-dimethoxybenzene (89 ml, 0.064 mole) in dry tetrahydrofuran (480 ml) was added during 10 minutes to a stirred solution of n-butyl lithium in hexane (350 ml, 0.6 mole) under an atmosphere of nitrogen. The stirred mixture was heated under reflux for 90 minutes, then a solution of N-methyl succinimide (77 g, 0.68 mole) in dry tetrahydrofuran was added dropwise. The mixture was heated under reflux for an additional hour and then allowed to stand overnight. The supernatant was decanted and the residue was hydrolysed with 20% aqueous ammonium chloride solution (280 ml) and extracted with chloroform. The washed and dried extract was evaporated and the residue recrystallised from ethyl acetate to give N-methyl 3-(2,6-dimethoxybenzoyl)propionamide (15 g, 10%, m.p. 134°).

Aufarbeitung

  1. temperatureThe stirred mixture was heated
  2. temperatureunder reflux for 90 minutes
  3. temperatureThe mixture was heated
  4. temperatureunder reflux for an additional hour
  5. customThe supernatant was decanted
  6. extractionextracted with chloroform
  7. washThe washed
  8. customdried
  9. extractionextract
  10. customwas evaporated
  11. customthe residue recrystallised from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-140938eba04c44969a14bf17b6eb5754
Quelldatensatz
uspto-grants-1977_10
Patentnummer
US04053601

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