Tert-Butylamine → HCID 20309603, Verbindung

HRID 972796Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 972796
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([O:19][CH2:20][CH:21]2[O:23][CH2:22]2)=[C:9]([CH:18]=1)[C:10]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])(=[O:3])[CH3:2].[C:24]([NH2:28])([CH3:27])([CH3:26])[CH3:25]>CO>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([O:19][CH2:20][CH:21]([OH:23])[CH2:22][NH:28][C:24]([CH3:27])([CH3:26])[CH3:25])=[C:9]([CH:18]=1)[C:10]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 6385Tert-ButylamineHCID 20309567HCID 20309567, Verbindung

Produkt 1

HCID 20309603HCID 20309603, VerbindungAusbeute 33 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of methyl 3-[5-acetamido-2-(2,3-epoxypropoxy)benzoyl]propionate (0.52 g, 0.0016 mole), t-butylamine (20 ml) and methanol (10 ml) was heated under reflux for 16 hours. Evaporation of the reaction mixture left an oil which was dissolved in ethanol and treated with ether to give crystalline methyl 3-[5-acetamido-2-(3-t-butylamino-2-hydroxypropoxy)benzoyl]propionate (0.21 g, 33%; m.p. 127°-128°).

Aufarbeitung

  1. temperatureunder reflux for 16 hours
  2. customEvaporation of the reaction mixture
  3. waitleft an oil which
  4. dissolutionwas dissolved in ethanol
  5. additiontreated with ether

Quellen und Nachweise

ORD-Eintrag
ord-2454a1286b5940128dce8d8198923ab1
Quelldatensatz
uspto-grants-1977_10
Patentnummer
US04053601

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