Ethylamine → HCID 68122832, Verbindung

HRID 973121Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 973121
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6](Cl)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1.C([N:18]([CH2:21][CH3:22])CC)C.[CH2:23]([NH2:25])[CH3:24]>C(O)C>[CH2:23]([NH:25][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([NH:18][CH2:21][CH3:22])[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1)[CH3:24]

Komponenten

5

Edukt 3

HCID 6341EthylamineHCID 8471TriethylamineHCID 214008694,6-Dichloro-5-nitro-2-(trifluoromethyl)pyrimidine

Produkt 1

HCID 68122832HCID 68122832, VerbindungAusbeute 98,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

5.25 g (0.02 mol) of 4,6-dichloro-5-nitro-2-trifluoromethyl-pyrimidine (J. Org. Chem. 26 (1961), pp. 4504-8) are dissolved in 150 ml of abs. ethanol. The solution is treated with 5 ml of triethylamine (0.05 mol) and 4.5 g (0.1 mol) of ethylamine and the mixture is stirred overnight, then evaporated to dryness. The residue is taken up in ether and washed with water. The ethereal phase is dried and concentrated to yield 5.5 g of 4,6-bis-ethylamino-5-nitro-2-trifluoromethyl-pyrimidine; m.p. 60°-65° C.

Aufarbeitung

  1. dissolution4504-8) are dissolved in 150 ml of abs
  2. customevaporated to dryness
  3. washwashed with water
  4. customThe ethereal phase is dried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-4d8667de238e48dc9ca1cb45d690dc9e
Quelldatensatz
uspto-grants-1977_10
Patentnummer
US04055411

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