4-Hydroxybenzaldehyde → 4-[(3-Chlorophenyl)methoxy]benzaldehyde

HRID 973392Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 973392
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20]Cl>C(C(C)=O)C>[Cl:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20][O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 1264-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 12103m,alpha-Dichlorotoluene

Produkt 1

HCID 7354654-[(3-Chlorophenyl)methoxy]benzaldehydeAusbeute 88,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

18.3 g of p-hydroxybenzaldehyde is dissolved in 200 ml of methyl ethyl ketone, and then 22.8 g of potassium carbonate and 24.2 g of m-chlorobenzyl chloride are added thereto. The resulting mixture is refluxed for 8 hours in a stream of nitrogen. Insoluble substances produced are removed by filtration, and then the solvent is distilled away. The resulting residue is distilled under reduced pressure to obtain 32.6 g of 4-(3-chlorobenzyloxy)benzaldehyde in the form of white crystal.

Aufarbeitung

  1. temperatureThe resulting mixture is refluxed for 8 hours in a stream of nitrogen
  2. customInsoluble substances produced
  3. customare removed by filtration
  4. distillationthe solvent is distilled away
  5. distillationThe resulting residue is distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-078a98a913304fd1865101b59fb60f94
Quelldatensatz
uspto-grants-1991_11
Patentnummer
US05063197

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