Magnesium monoxide → 1-(5-Ethoxycarbonylpyrid-2-yl)-2-methylimidazo[4,5-c]pyridine

HRID 973490Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 973490
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:22])[N:10]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][N:12]=3)[C:6]=2[CH:5]=[CH:4][N:3]=1.[O-2].[Mg+2]>C(O)C.[Pd]>[CH2:20]([O:19][C:17]([C:14]1[CH:15]=[CH:16][C:11]([N:10]2[C:6]3[CH:5]=[CH:4][N:3]=[CH:2][C:7]=3[N:8]=[C:9]2[CH3:22])=[N:12][CH:13]=1)=[O:18])[CH3:21]

Komponenten

5

Edukt 2

HCID 6850729Magnesium monoxideHCID 198771824-Chloro-1-(5-ethoxycarbonylpyrid-2-yl)-2-methylimidazo[4,5-c]pyridine

Produkt 1

HCID 198771831-(5-Ethoxycarbonylpyrid-2-yl)-2-methylimidazo[4,5-c]pyridineAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 4-chloro-1-(5-ethoxycarbonylpyrid-2-yl)-2-methylimidazo[4,5-c]pyridine in ethanol (100 ml) was hydrogenated over 30% palladium on carbon (3 g) and magnesium oxide (0.8 g) at 50 p.s.i. (345 kPa) for 30 hours. The mixture was filtered through Arbocel filter aid and the filter cake washed with boiling ethanol (6×50 ml). The filtrate was concentrated under reduced pressure yielding the title compound as a white foam, (2.75 g, 96%).

Aufarbeitung

  1. filtrationThe mixture was filtered through Arbocel
  2. filtrationfilter aid
  3. washthe filter cake washed with boiling ethanol (6×50 ml)
  4. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ad12d5201b7c4367b331edb3adaddd54
Quelldatensatz
uspto-grants-1991_11
Patentnummer
US05063237

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