Triethylamine → HCID 56617740, Verbindung

HRID 974262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 974262
[CH:1]1([CH2:4][NH:5][C:6]2[N:14]=[CH:13][N:12]=[C:11]3[C:7]=2[N:8]=[CH:9][N:10]3[C@H:15]2[CH2:19][CH2:18][C@@H:17]([CH2:20][OH:21])[O:16]2)[CH2:3][CH2:2]1.C(N(CC)CC)C.[C:29](Cl)(=[O:35])[CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>CN(C)C1C=CN=CC=1.C(#N)C>[CH:1]1([CH2:4][NH:5][C:6]2[N:14]=[CH:13][N:12]=[C:11]3[C:7]=2[N:8]=[CH:9][N:10]3[C@H:15]2[CH2:19][CH2:18][C@@H:17]([CH2:20][O:21][C:29](=[O:35])[CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[O:16]2)[CH2:2][CH2:3]1

Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 67340Hexanoyl chlorideHCID 18649770HCID 18649770, Verbindung

Produkt 1

HCID 56617740HCID 56617740, VerbindungAusbeute 40,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

6-(Cyclopropylmethylamino)-9-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furyl]-9H-purine (0.503 g, 1.7 mmoles), triethylamine (2.0 mL, 14 mmoles, Aldrich Chemical Co., Madison, Wis.), and 4-dimethylaminopyridine (10 mg, 0.1 mmoles, Aldrich Chemical Co., Madison, Wis.) were dissolved in 50 mL acetonitrile. Hexanoyl chloride (980 μl, 7.0 mmoles, Aldrich Chemical Co., Madison, Wis.) was added and the reaction was stirred at room temperature for 3 hours. The reaction was quenched with methanol and solvents were evaporated in vacuo. The residue was dissolved in 25 mL ethyl acetate and undissolved salts were removed by filtration. After evaporation of the ethyl acetate, the residue was dissolved in methanol and passed over a silica gel column (4.8×13 cm). The product containing fractions were combined, concentrated, and chromatographed on a Chromatotron (4 mm silica gel plate) with a mixture of hexane:acetone (8:2). The product was further purified on the Chromatotron (2 mm silica gel plate) with a mixture of chloroform:acetone (99:1). Lyophilization afforded 0.268 g of 6-(cyclopropylmethylamino)-9-[(2R,5S)-5-[(hexanoyloxy)methyl]-tetrahydro-2-furyl]-9H-purine as an oil (40% yield).

Aufarbeitung

  1. customThe reaction was quenched with methanol and solvents
  2. customwere evaporated in vacuo
  3. dissolutionThe residue was dissolved in 25 mL ethyl acetate
  4. customundissolved salts were removed by filtration
  5. customAfter evaporation of the ethyl acetate
  6. dissolutionthe residue was dissolved in methanol
  7. additionThe product containing fractions
  8. concentrationconcentrated
  9. customchromatographed on a Chromatotron (4 mm silica gel plate) with a mixture of hexane:acetone (8:2)
  10. customThe product was further purified on the Chromatotron (2 mm silica gel plate) with a mixture of chloroform:acetone (99:1)

Quellen und Nachweise

ORD-Eintrag
ord-b945042a63ff45dca39a482b9c9bc572
Quelldatensatz
uspto-grants-1991_11
Patentnummer
US05068320

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