Water → Meridia

HRID 974527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 974527
Cl.[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].[OH2:21]>C1(C)C=CC=CC=1>[OH2:21].[ClH:20].[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4]

Komponenten

4

Edukt 2

HCID 962WaterHCID 64764Sibutramine Hydrochloride

Produkt 1

HCID 64765Meridia

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride (5 g) was dissolved in a boiling mixture of toluene (126 ml) and water (12.6 ml). The solution was filtered whilst hot and the filtrate cooled. The product crystallised from the cooled filtrate and was collected by filtration and dried in vacuo at ambient temperature to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (m.p. 194°-196° C.).

Aufarbeitung

  1. filtrationThe solution was filtered whilst hot and the filtrate
  2. temperaturecooled
  3. customThe product crystallised from the cooled filtrate
  4. filtrationwas collected by filtration
  5. customdried in vacuo at ambient temperature

Quellen und Nachweise

ORD-Eintrag
ord-eada22b79e60499c897fdf45035a69b7
Quelldatensatz
uspto-grants-1991_11
Patentnummer
US05068440

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