Acetone → Meridia

HRID 974528Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 974528
Cl.[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].CC(C)=[O:23]>O>[OH2:23].[ClH:20].[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4]

Komponenten

4

Edukt 2

HCID 180AcetoneHCID 64764Sibutramine Hydrochloride

Produkt 1

HCID 64765Meridia

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride (10 g) was dissolved in a boiling mixture of acetone (110 ml) and water (1.2 ml). The solution was filtered whilst hot and the volume of the filtrate reduced by the removal by distillation of 80 ml of solvent. The product was collected from the cooled concentrate by filtration and dried in vacuo at ambient temperature to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (m.p. 195° C.).

Aufarbeitung

  1. filtrationThe solution was filtered whilst hot and the volume of the filtrate
  2. customreduced by the removal by distillation of 80 ml of solvent
  3. customThe product was collected from the cooled
  4. concentrationconcentrate by filtration
  5. customdried in vacuo at ambient temperature

Quellen und Nachweise

ORD-Eintrag
ord-99c3114c5f71476ea11f27980dc46c35
Quelldatensatz
uspto-grants-1991_11
Patentnummer
US05068440

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