6-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine → Octahydropyrrolo[3,4-b][1,4]oxazine

HRID 974892Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 974892
C([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][O:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH:15]12[CH2:16][NH:8][CH2:9][CH:10]1[NH:11][CH2:12][CH2:13][O:14]2

Komponenten

4

Edukt 1

HCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

Produkt 1

HCID 15069981Octahydropyrrolo[3,4-b][1,4]oxazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

7.2 g (33 mmol) of 8-benzyl-2-oxa-5,8-diazabicyclo-[4.3.0]nonane are hydrogenated in 400 ml of methanol with 2.5 g of palladium-on-active charcoal (10% of Pd) under 50 bar at 100° C. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Aufarbeitung

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-406c9d82f6e647afb643d65bc0b2c189
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05607942

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