N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide → 3-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidine

HRID 975008Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 975008
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH:15]([N:18]3C(=O)C4=CC=CC=C4C3=O)[CH2:14]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>C(O)C.O.NN>[NH2:18][CH:15]1[CH2:16][CH2:17][N:13]([CH2:12][CH2:11][C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:14]1

Komponenten

4

Edukt 1

HCID 15045352N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide

Produkt 1

HCID 150453533-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidineAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 24654Hydrazine hydrate (1:1)Lösungsmittel

Versuchsvorschrift

1.03 g of N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide was dissolved in 50 ml of ethanol, to which 2 ml of hydrazine monohydrate was added and refluxed under heating for 14 hours. The solvent was distilled off and an aqueous diluted solution of sodium hydroxide was added to the residue and extracted with chloroform. After drying with anhydrous magnesium sulfate, the solvent was distilled off, to obtain 0.68 g of the above-captioned compound (yield: 100%).

Aufarbeitung

  1. additionwas added
  2. temperaturerefluxed
  3. temperatureunder heating for 14 hours
  4. distillationThe solvent was distilled off
  5. additionan aqueous diluted solution of sodium hydroxide was added to the residue
  6. extractionextracted with chloroform
  7. dry with materialAfter drying with anhydrous magnesium sulfate
  8. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-b250f5a3ce1b4366a25bd1e78bb20778
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05607953

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