2,2,2-Trifluoroacetophenone → 2,2,2-Trifluoro-1-phenyl-ethanone oxime

HRID 975243Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 975243
[Cl-].[OH:2][NH3+:3].[F:4][C:5]([F:15])([F:14])[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O>C(O)C>[F:4][C:5]([F:15])([F:14])[C:6](=[N:3][OH:2])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 99052,2,2-TrifluoroacetophenoneHCID 21645Hydroxylamine HCl

Produkt 1

HCID 6049312,2,2-Trifluoro-1-phenyl-ethanone oximeAusbeute 80,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of hydroxylammonium chloride (13.9 g, 200 mmol) and 2,2,2-trifluoroacetophenone (17.4 g, 92 mmol) in absolute ethanol (150 ml) was heated at reflux for 1 h and then stirred at ambient temperature for 16 h. The solvent was evaporated in vacuo, the residue suspended in water (100 ml), filtered and washed with water (20 ml), n-heptane (20 ml) and dried to give 14.0 g 2,2,2-trifluoroacetophenone oxime.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 1 h
  3. customThe solvent was evaporated in vacuo
  4. filtrationfiltered
  5. washwashed with water (20 ml), n-heptane (20 ml)
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-15feefc887b843909ce932fa4a8671a0
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05608069

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