Water → 9,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

HRID 975862Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 975862
[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:7]1[C:11]2[NH:12][C:13](=O)[C:14]3[N:15]([CH:17]=[CH:18][CH:19]=3)[CH2:16][C:10]=2[CH:9]=[CH:8]1.O.[OH-].[Na+]>O1CCCC1>[O:7]1[C:11]2[NH:12][CH2:13][C:14]3[N:15]([CH:17]=[CH:18][CH:19]=3)[CH2:16][C:10]=2[CH:9]=[CH:8]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 100133324,10-dihydro-9H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepin-9-oneHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 218369669,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of 4 mmol of lithium aluminum hydride in 25 ml of anhydrous tetrahydrofuran is added 1 mmol of 9,10-dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]-diazepin-9-one. The mixture is refluxed for 12 hours and allowed to stand overnight. To the mixture is added dropwise 0.12 ml of water and then 6 ml of 1N sodium hydroxide. The mixture is extracted with ethyl acetate and the extract dried (Na2SO4). The volatiles are removed in vacuo to give the desired product as a solid.

Aufarbeitung

  1. temperatureThe mixture is refluxed for 12 hours
  2. extractionThe mixture is extracted with ethyl acetate
  3. dry with materialthe extract dried (Na2SO4)
  4. customThe volatiles are removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-562c56f861e34db8bc6635a0465a3d3b
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05610156

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