Hydrochloric Acid → (E)-4-[3-(1-benzylpiperidin-4-yl)propenoyl]aniline

HRID 976140Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 976140
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11](/[CH:14]=[CH:15]/[C:16]([C:18]2[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C(O)(=O)C>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11](/[CH:14]=[CH:15]/[C:16]([C:18]2[CH:19]=[CH:20][C:21]([NH2:24])=[CH:22][CH:23]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 70279862(E)-4-[3-(1-benzylpiperidin-4-yl)propenoyl]nitrobenzene

Produkt 1

HCID 19968908(E)-4-[3-(1-benzylpiperidin-4-yl)propenoyl]aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

1.27 g of (E)-4-[3-(1-benzylpiperidin-4-yl)propenoyl]nitrobenzene was added to a mixed solution of 10 ml of acetic acid and 2 ml of hydrochloric acid, and then 1.38 g of stannous chloride was added thereto under ice cooling. The mixture was stirred for 24 hours. During the reaction, 0.69 g of stannous chloride was further added twice. After completion of the reaction, the reaction mixture was condensed under reduced pressure to obtain 5.50 g of a crude product of the title compound. This was used without purification for the next reaction.

Aufarbeitung

  1. additionwas further added twice
  2. customAfter completion of the reaction
  3. customcondensed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f358fc38bacd4c36af71ca2eff7151e2
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05610303

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