Methyl 3-[3,5-Diisopropyl-4-(1-phenyltetrazol-5-yloxy)benzoyl]propionate → Methyl 3-(3,5-diisopropylbenzoyl)propionate

HRID 976352Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 976352
[CH:1]([C:4]1[CH:5]=[C:6]([CH:15]=[C:16]([CH:30]([CH3:32])[CH3:31])[C:17]=1OC1N(C2C=CC=CC=2)N=NN=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])([CH3:3])[CH3:2]>C1C=CC=CC=1.[Pd]>[CH:1]([C:4]1[CH:5]=[C:6]([CH:15]=[C:16]([CH:30]([CH3:32])[CH3:31])[CH:17]=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])([CH3:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 19967146Methyl 3-[3,5-Diisopropyl-4-(1-phenyltetrazol-5-yloxy)benzoyl]propionate

Produkt 1

HCID 19967165Methyl 3-(3,5-diisopropylbenzoyl)propionateAusbeute 71,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 241BenzeneLösungsmittel

Versuchsvorschrift

14.1 g of Methyl 3-[3,5-diisopropyl-4-(1-phenyltetrazol-5-yloxy)benzoyl]propionate was dissolved in 100 ml of benzene, followed by the addition of 10 g of 10% palladium/carbon. The obtained mixture was subjected to hydrogenation under a pressure of 3 kg/cm2, at room temperature for 14 hours. The reaction mixture thus obtained was filtered to remove the catalyst. The filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (developer: 3% ethyl acetate/n-hexane) to give 6.4 g of the title compound as a colorless oil.

Aufarbeitung

  1. customThe reaction mixture thus obtained
  2. filtrationwas filtered
  3. customto remove the catalyst
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customThe obtained residue was purified by silica gel chromatography (developer: 3% ethyl acetate/n-hexane)

Quellen und Nachweise

ORD-Eintrag
ord-3a3b8643fb8147ee844d1f66562560c3
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05612356

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