Water → (1R,2S)-(+)-cis-1-Amino-2-indanol

HRID 976956

Reaktionsgleichung

Reaktionsgleichung von HRID 976956
[C@@H:1]1(O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@@H:2]1[OH:10].S(=O)(=O)(O)O.O.[OH-].[Na+].C(#[N:22])C>>[NH2:22][C@@H:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@@H:2]1[OH:10]

Komponenten

6

Edukt 5

HCID 962WaterHCID 1118Sulfuric AcidHCID 6342AcetonitrileHCID 14798Sodium HydroxideHCID 20758cis-1,2-Indandiol

Produkt 1

HCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanol

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Cis-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C, and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol.

Aufarbeitung

  1. temperatureThe mixture was gradually warmed to 20° C. and aged to 3 hours
  2. temperaturethe mixture heated to reflux
  3. customThe resulting solid was removed by filtration

Quellen und Nachweise

ORD-Eintrag
ord-e75ea48617e8497492e1911921de0bc3
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05612484

Verknüpfte Notizen

Wird geladen…