Hydrochloric Acid → N-nitro-N-methyl-L-phenylalanine

HRID 977003

Reaktionsgleichung

Reaktionsgleichung von HRID 977003
[CH3:1][NH:2][C@H:3]([C:11]([OH:13])=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl.[N:15]([O-:17])=[O:16].[Na+]>O>[N+:15]([N:2]([CH3:1])[C@H:3]([C:11]([OH:13])=[O:12])[CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)([O-:17])=[O:16]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6951135N-MethylphenylalanineHCID 23668193Sodium Nitrite

Produkt 1

HCID 54111718N-nitro-N-methyl-L-phenylalanine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

N-Methyl-L-phenylalamne (2.50 g) was suspended in water (25 ml) and cone. HCl (1 ml) was addded, with stirring. The solution was cooled to 5° C. and solid sodium nitrite (1.35 g) was added to the stirred solution. After stirring at 5° C. for 1 h, the reaction mixture was partitioned between dichloromethane and water. The organic solution was washed with brine and dried (MgSO4). After filtration the solvent was evaporated to yield N-nitro-N-methyl-L-phenylalanine as a white solid.

Aufarbeitung

  1. stirringAfter stirring at 5° C. for 1 h
  2. customthe reaction mixture was partitioned between dichloromethane and water
  3. washThe organic solution was washed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationAfter filtration the solvent
  6. customwas evaporated

Quellen und Nachweise

ORD-Eintrag
ord-ba84df62857b43a99259d3b989f623be
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05612477

Verknüpfte Notizen

Wird geladen…