Water → 3-(4-Cyanophenyl)-2-oxo-5-oxazolidinecarboxylic acid

HRID 977209

Reaktionsgleichung

Reaktionsgleichung von HRID 977209
[O:1]=[C:2]1[N:6]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:5][CH:4]([CH2:15][OH:16])[O:3]1.ClCCl.[OH2:20]>C(#N)C>[C:11]([C:10]1[CH:13]=[CH:14][C:7]([N:6]2[CH2:5][CH:4]([C:15]([OH:20])=[O:16])[O:3][C:2]2=[O:1])=[CH:8][CH:9]=1)#[N:12]

Komponenten

5

Edukt 3

HCID 962WaterHCID 6344DichloromethaneHCID 15591328HCID 15591328, Verbindung

Produkt 1

HCID 153409393-(4-Cyanophenyl)-2-oxo-5-oxazolidinecarboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

1 g of 4-(2-oxo-5-hydroxymethyloxazolidin-3-yl)benzonitrile [obtainable according to EP 300 272] dissolved in 12 ml of acetonitrile is added at 16° to a solution of 3.6 g of Na dihydrogen phosphate dihydrate, 3.9 g of Na metaperiodate and 36 mg of RuCl3 in 23 ml of water/2.3 ml of dichloromethane. The reaction mixture is stirred at room temperature for 12 h, filtered and given the customary workup. Concentration by evaporation to dryness in vacuo gives 3-(4-cyanophenyl)-2-oxo-5-oxazolidinecarboxylic acid, m.p. 204°.

Aufarbeitung

  1. filtrationfiltered
  2. concentrationConcentration
  3. customby evaporation to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-66fecb73f96c4f3093a98af5ec58796c
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05614535

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