Sodium Carbonate → Sodium 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate

HRID 979138Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 979138
[CH3:1][CH:2]([CH3:22])[CH2:3][O:4][C:5]1[CH:21]=[CH:20][CH:19]=[CH:18][C:6]=1[NH:7][C:8]1[NH:9][C:10](=[O:17])[C:11]([C:14]([OH:16])=[O:15])=[CH:12][N:13]=1.C(=O)([O-])[O-].[Na+:27].[Na+]>C(O)C.O>[CH3:1][CH:2]([CH3:22])[CH2:3][O:4][C:5]1[CH:21]=[CH:20][CH:19]=[CH:18][C:6]=1[NH:7][C:8]1[NH:9][C:10](=[O:17])[C:11]([C:14]([O-:16])=[O:15])=[CH:12][N:13]=1.[Na+:27]

Komponenten

5

Edukt 2

HCID 10340Sodium CarbonateHCID 9817898Mar 99

Produkt 1

HCID 23692303Sodium 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylateAusbeute 57,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid (20 g) and sodium carbonate (7.0 g) in ethanol (100 ml) and water (100 ml) is heated until the solution is completed. After allowing to stand the solution overnight, the precipitate is collected by filtration, washed with water and dried to give sodium 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate (12.4 g). M.p. 231°-233° C.

Aufarbeitung

  1. temperatureis heated until the solution
  2. customthe solution overnight
  3. filtrationthe precipitate is collected by filtration
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-245f2c7448ab4c7e88f50af9908cd9d3
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04666915

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