Sodium Methoxide → 1-[4-(2-Methoxyethoxy)phenyl]methanamine

HRID 979786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 979786
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1.[CH3:13][O-:14].[Na+]>C1(C)C=CC=CC=1.CO>[CH3:13][O:14][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1

Komponenten

5

Edukt 2

HCID 10942334Sodium MethoxideHCID 202228754-(2-Chloroethoxy)benzylamine

Produkt 1

HCID 202228351-[4-(2-Methoxyethoxy)phenyl]methanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 1140TolueneLösungsmittel

Versuchsvorschrift

4-(2-Chloroethoxy)benzylamine (2.0 g; 0,11 mol) was dissolved in anhydrous toluene (50 ml). The reaction mixture was ice-cooled and sodium methoxide (0.59 g; 0.011 mol) dissolved in methanol (5 ml) was added thereto. When the addition was complete the mixture was left to stand for 2 hours at room temperature and filtered. Solvent was evaporated from the filtrate, to give an oily residue of good purity.

Aufarbeitung

  1. temperaturecooled
  2. additionwas added
  3. additionWhen the addition
  4. waitwas left
  5. filtrationfiltered
  6. customSolvent was evaporated from the filtrate
  7. customto give an oily residue of good purity

Quellen und Nachweise

ORD-Eintrag
ord-af266a91e9b84dd09eeb033e3f4830d6
Quelldatensatz
uspto-grants-1987_01
Patentnummer
US04634701

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