Diethyl Ether → HCID 20159920, Verbindung

HRID 980009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 980009
C(OC([NH:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15])=O)(C)(C)C.C(OCC)C>FC(F)(F)C(O)=O>[NH2:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15]

Komponenten

4

Edukt 2

HCID 3283Diethyl EtherHCID 20159947HCID 20159947, Verbindung

Produkt 1

HCID 20159920HCID 20159920, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

In 30 ml of trifluoroacetic acid was dissolved 6.0 g of N-(4-t-butoxycarbonylamino-3-phenylbutyl)-5-isoquinolinesulfonamide, and left at a temperature of 20° C.~25° C. for 30 minutes. The mixrure was condensed under reduced pressure. To the reaction solution was added ethyl ether, and the crystals precipitated were separated by filtration. The crystals thus obtained were washed with ethylether to give 4.54 g of N-(4-amino-3-phenylbutyl)-5-isoquinolinesulfonamide in a yield of 97%.

Aufarbeitung

  1. customcondensed under reduced pressure
  2. customthe crystals precipitated
  3. customwere separated by filtration
  4. customThe crystals thus obtained
  5. washwere washed with ethylether

Quellen und Nachweise

ORD-Eintrag
ord-a15db979ebc54b889a356f3f03824796
Quelldatensatz
uspto-grants-1987_01
Patentnummer
US04634770

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